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KMID : 0370220030470050271
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Yakhak Hoeji
2003 Volume.47 No. 5 p.271 ~ p.275
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Synthesis of 4’a-C Methyl Branched Novel Adenine and Uracil Carbocyclic Nucleosides Using Ring-Closing Metathesis
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Joon Hee Hong
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Abstract
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Easy and efficient synthetic route of novel 4’-C methyl branched carbocyclic nucleosides is described. The installation of alkyl and aryl groups at 4’-position of carbocyclic nucleosides were successfully made via sequential [3,3]- sigmatropic rearrangement and ring-closing metathesis (RCM) starting from simple ketones such as acetol. Adenine and uracil were coupled via Pd(0) catalyzed reaction, followed by desilylation to give novel compounds 13 and 14, respectively.
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KEYWORD
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